Y-Chromosome Studies

  • Haplotype M3 present in 66% of NA males found in Chukotka peninsula in Siberia

  • Haplotype M45 present in 25% of NA males found in Lower Amur River and Sea of Okhotsk regions of eastern Siberia

  • Haplotype RPS4Y-T present in 5% of NA males found in the Lower Amur River/Sea of Okhotsk region of Siberia

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Slide 34 of 56


Haplotype M3, accounted for 66% of male Y-chromosomes and was found associated with native populations from the Chukotka peninsula in Siberia, adjacent to Alaska. The second major group of Native American Y-chromosomes, haplotype M45, accounted for about one-quarter of male lineages. This haplotype was found in the Lower Amur River and Sea of Okhotsk regions of eastern Siberia. The remaining 5% of Native American Y-chromosomes were of haplotype RPS4Y-T, which was found in the Lower Amur River/Sea of Okhotsk region of Siberia. These data suggested that Native American male lineages were derived from two major Siberian migrations.1


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  1. Lell JT, Sukernik RI, Starikovskaya YB, Su B, Jin L, Schurr TG, Underhill PA, Wallace DC. 2002. The dual origin and Siberian affinities of Native American One of the two sex chromosomes that determines maleness in mammals, carried and passed down from males to males.Y Chromosomes. Am. J. Hum. Genet. 2002 70:192-206.

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