Human One of the threadlike "packages" of genes and other DNA in the nucleus of a cell. Different kinds of organisms have different numbers of chromosomes. Humans have 23 pairs of chromosomes, 46 in all: 44 autosomes and two sex chromosomes. Each parent contributes one chromosome to each pair, so children get half of their chromosomes from their mothers and half from their fathers.Chromosome 21 Diversity

Chromosome 21

  • Three haplotypes describe 80% of human population

  • Far fewer haplotypes than expected

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Slide 28 of 109


In a detailed genetic analysis of human One of the threadlike "packages" of genes and other DNA in the nucleus of a cell. Different kinds of organisms have different numbers of chromosomes. Humans have 23 pairs of chromosomes, 46 in all: 44 autosomes and two sex chromosomes. Each parent contributes one chromosome to each pair, so children get half of their chromosomes from their mothers and half from their fathers.chromosome 21, scientists have found that the vast majority of human populations around the globe fall into only three haplotypes.1 This limited degree of genetic diversity was unexpected for a species that, from an evolutionary viewpoint, had its origins millions of years ago.

Definitions

Haplotype
A combination of Variant forms of a gene at a particular locus, or location, on a chromosome.alleles (alternate forms of the same gene) of closely linked Multiple places on a chromosome where specific genes or genetic markers are located, a kind of address for the gene.loci that are found in a single chromosome and tend to be inherited together.

References

  1. Alfred, J. 2002. MULTIFACTORIAL GENETICS - Wafer thin diversity. Nature Reviews Genetics 3: 6.

 

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