Origin of the Malaria Parasite

  • Human chromosomesOriginated less than 120,000 ya

  • Resistance Variant forms of a gene at a particular locus, or location, on a chromosome.alleles appeared 3,000-12,000 ya

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Slide 35 of 109


Depending upon which study one examines the Variant forms of a gene at a particular locus, or location, on a chromosome.alleles that confer malarial resistance arose either 120,0001 or 3,000-12,0002 year ago.


References Top of page

  1. Mu, J., J. Duan, K. D. Makova, D. A. Joy, C. Q. Huynh, O. H. Branch, W. Li and X. Su. 2002. One of the threadlike "packages" of genes and other DNA in the nucleus of a cell. Different kinds of organisms have different numbers of chromosomes. Humans have 23 pairs of chromosomes, 46 in all: 44 autosomes and two sex chromosomes. Each parent contributes one chromosome to each pair, so children get half of their chromosomes from their mothers and half from their fathers.Chromosome-wide Single nucleotide polymorphisms are a common, but minute, variations that occurs in human DNA at a frequency of one every 1,000 bases, often used to track inheritance.SNPs reveal an ancient origin for Plasmodium falciparum. Nature 418: 323324.

  2. Tishkoff, S.A., et al. 2001. Haplotype Diversity and Linkage Disequilibrium at Human G6PD: Recent Origin of Variant forms of a gene at a particular locus, or location, on a chromosome.AllelesThat Confer Malarial Resistance. Science 293: 455-462.

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Last Modified June 21, 2006

 

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