Beanybag wrote:KBCid, why don't you try to find a biologist, or some more qualified experts to work on this paper with? At the very least, you could try to investigate the necessary and sufficient requirements for 3d-spatial positioning. Perhaps work with a chemist or biochemist as well, get a team together, and do the research?
What makes a biologist more qualified then me when it comes to physics? How many control systems do biologists construct?
I do already have two biologists that are in collaboration with me on this subject and another engineer and we are defining ways to make empirical tests. It simply will take time to implement since there isn't tons of money being given out to help disprove the evolutionary theory.
The one thing you should consider is that these people are on board with the concept based entirely on the logic of the physics of the systems mechanics which they could not find a logical way around and they tried for months to find a week point without success. The great thng from my POV is that it was physics that does the convincing and not simply an opinion from a nobody.
It will be interesting when this becomes more mainstream to see how evo's will try to overcome the laws of physics to keep their hypothesis relevant. Even with this short time online there has been no realistic argument that can be applied against it. Of course I spent a year on the subject with 4 months of that in collaboration to ensure that I didn't overlook something.
So no worries, my homework is done and the right people are in collaboration to take it forward. All I have to do now is help with researching the historical work already performed and lend a mechanical hand as needed when they run into any sticky points. Physics is a wonderfull thing.
There has already been some aspects of the concept brought forth last year...
Society for Developmental Biology Annual Meeting, Chicago, IL, July 2011
Gene Regulatory Networks in Embryos Depend on Pre-existing Spatial Coordinates
Abstract #347
Jonathan Wells
Discovery Institute, 208 Columbia Street, Seattle, WA 98104
The development of metazoan embryos requires the precise spatial deployment of specific cellular functions. This deployment depends on gene regulatory networks (GRNs), which operate downstream of initial spatial inputs (E. H. Davidson, Nature 468 [2010]: 911). Those initial inputs depend, in turn, on pre-existing spatial coordinate systems...
“Ultimately, the beginning of spatial information in the embryo often traces back to asymmetrically distributed molecules deposited in the egg during its production in the ovary that initiate the formation of the two main axes of the embryo (so the egg did come before the chicken).”
William E. Theurkauf & Tulle I. Hazelrigg, “In vivo analyses of cytoplasmic transport and cytoskeletal organization during Drosophila oogenesis: characterization of a multi-step anterior localization pathway,” Development 125 (1998): 3655-3666.
Kevin M. Forrest & Elizabeth R. Gavis, “Live Imaging of Endogenous RNA Reveals a Diffusion and Entrapment Mechanism for nanos mRNA Localization in Drosophila,” Current Biology 13 (2003): 1159-1168.
Uwe Irion & Daniel St. Johnston, “Bicoid RNA localization requires specific binding of an endosomal sorting complex,” Nature 445 (2007): 554-558.
Musa M. Mhlanga, et al., “In vivo colocalisation of oskar mRNA and trans-acting proteins revealed by quantitative imaging of the Drosophila oocyte,” PLoS One 4 (2009): e6241.
“Composition of cellular organelles and their membranes is constant from one generation to the next. This latter property of organelles, when considered with the fact that membranes do not form de novo, has led to the proposal that cell membranes and their constituent proteins have
temporal continuity ...
...Realizing that genetic memory is one dimensional, along a DNA molecule, whereas spatial memory is likely to be two-dimensional, along membrane surfaces, and three-dimensional within the cellular interior, it is probable that spatial memory is more complicated and diverse than genetic memory.”
Robert O. Poyton, “Memory and Membranes: Expression of Genetic and Spatial Memory During the Assembly of Organelle Macrocompartments,” Modern Cell Biology 2 (1983): 15-72.
According to Poyton’s hypothesis, although the molecules in a membrane pattern may be encoded by DNA, the membrane pattern itself pre-exists their synthesis.
EVOLUTIONARY IMPLICATIONS
Evolutionary developmental biology needs a more adequate explanation for the sources of spatial asymmetries—including membrane patterns— in the zygote.
http://www.discovery.org/scripts/viewDB ... ad&id=7751
Does this sound a bit familiar?