Biology of life and 3D spatial positioning
Posted: Wed Jun 27, 2012 10:26 am
I believe a thread dealing specifically with 3D spatial positioning and the formation of living systems is now something we can begin to discuss.
I will post relevant scientific articles to this discussion in this initial post and we can then tackle the understandings about it. Bippy this thread was conceived after our discussion in another area. If you find any further papers dealing with the subject, post it and i'll add them to this first post to give us all a single reference post to work from.
Tissue-specific spatial organization of genomes
http://genomebiology.com/content/5/7/R44
Statistical Analysis of 3D Images Detects Regular Spatial Distributions of Centromeres and Chromocenters in Animal and Plant Nuclei
http://www.ploscompbiol.org/article/inf ... bi.1000853
Micro-environmental control of cell migration – myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics http://jcs.biologists.org/content/125/9/2244.abstract
Cancer Cell Migration in 3D https://aiche.confex.com/aiche/2012/web ... 71104.html
The trypanosome flagellum http://jcs.biologists.org/content/116/5/757.full.pdf
Analysis of spatial relationships in three dimensions: tools for the study of nerve cell patterning
http://www.biomedcentral.com/1471-2202/9/68/
Mechanosignaling to the Cell Nucleus and Gene Regulation http://www.annualreviews.org/doi/abs/10 ... de=biophys
Time-lapse Tuesday: A frog's electric face http://www.newscientist.com/blogs/nstv/ ... -face.html
Spatial Positioning
Abstract
The eukaryotic cell nucleus is a heterogeneous organelle. Chromosomes are nonrandomly positioned within the nuclear space, and individual gene loci experience distinct local environments due to the presence of chromatin domains and subnuclear compartments. Recent observations have highlighted the important yet still largely mysterious role of spatial positioning in genome activity and stability.
http://www.cell.com/abstract/S0092-8674(04)00944-4
Location, Location, Location http://www.sciencemag.org/content/326/5957/1205.short
Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis
http://dev.biologists.org/content/135/19/3209.abstract
Spatial Control of Cytokinesis by Cdr2 Kinase and Mid1/Anillin Nuclear Export
http://www.cell.com/current-biology/abs ... 09)00985-3
Three-dimensional organization of the mammalian nucleus in normal and tumor cells.
http://atlasgeneticsoncology.org/Deep/3 ... 20053.html
On emerging nuclear order
Increasing evidence suggests that the arrangement of chromosomes, gene loci, and nuclear bodies is nonrandom and exhibits features of self-organization in space and time...
Although mechanisms governing spatial positioning and how specific nuclear subcompartments at the periphery influence transcriptional state are not well understood, they appear to be important regulatory events in development.
http://jcb.rupress.org/content/192/5/711.full
Micropatterned environments in cell biology
http://www.seas.upenn.edu/~chenlab/pdf/ ... vMat04.pdf
LOL even the people from the wacko type sites are getting in the action....
Genetics: Does DNA also encode mathematical values of lengths, distances and angles?
Each organism eventually has a certain physical shape and in humans, this is inevitably 2 arms, 2 legs, a head, 2 ears, 2 eyes, hands, fingers, etc. Now these are obviously the external shape and appearance of the organism. But there are also internal 3 dimensional structures e.g. blood vessels, the brain, the heart, the liver, kidneys, stomach, etc, etc.
So where is the information stored that determines the "physical" 3 dimensional shape (internal and external) of the organism ? Presumably also somewhere within the DNA How is this information retrieved and used ?
The completed arm will have a physical shape thats recognizable as an arm which means that during the entire process of creating the arm, millions of cells will become involved and will require knowledge of their position in space and their position relative to all the other cells busily working away at creating their part of the arm. Otherwise if cells were allowed to simply divide and position themselves randomly, the foetus would most likely end up with a blob or some other weird shape for an arm.
The fact that an arm most times develops in the right place and looks like an arm, must mean that every cell that played a part in the construction of that arm must have also been supplied or had access to spatial positioning information and some kind of coordination system ... information that would say "get x number of cells to divide but only in THIS direction only and then stop ... then get y number of cells to divide but only in THIS different direction, then stop." http://www.abovetopsecret.com/forum/thread518463/pg1
Maybe they aren't so wacko after all....
Spatially dependent activation of the patterning protease, Easter
Easter is the final protease in a serine protease cascade in which initial reaction steps appear not to be ventrally restricted, but where Easter activity is promoted ventrally through the action of a spatial cue at an unknown step in the pathway. Here, biochemical studies demonstrate that this spatial control occurs at or above the level of Easter zymogen activation, rather than through direct promotion of Easter's catalytic activity against the signaling ligand. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644372/
I will post relevant scientific articles to this discussion in this initial post and we can then tackle the understandings about it. Bippy this thread was conceived after our discussion in another area. If you find any further papers dealing with the subject, post it and i'll add them to this first post to give us all a single reference post to work from.
Tissue-specific spatial organization of genomes
http://genomebiology.com/content/5/7/R44
Statistical Analysis of 3D Images Detects Regular Spatial Distributions of Centromeres and Chromocenters in Animal and Plant Nuclei
http://www.ploscompbiol.org/article/inf ... bi.1000853
Micro-environmental control of cell migration – myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics http://jcs.biologists.org/content/125/9/2244.abstract
Cancer Cell Migration in 3D https://aiche.confex.com/aiche/2012/web ... 71104.html
The trypanosome flagellum http://jcs.biologists.org/content/116/5/757.full.pdf
Analysis of spatial relationships in three dimensions: tools for the study of nerve cell patterning
http://www.biomedcentral.com/1471-2202/9/68/
Mechanosignaling to the Cell Nucleus and Gene Regulation http://www.annualreviews.org/doi/abs/10 ... de=biophys
Time-lapse Tuesday: A frog's electric face http://www.newscientist.com/blogs/nstv/ ... -face.html
Spatial Positioning
Abstract
The eukaryotic cell nucleus is a heterogeneous organelle. Chromosomes are nonrandomly positioned within the nuclear space, and individual gene loci experience distinct local environments due to the presence of chromatin domains and subnuclear compartments. Recent observations have highlighted the important yet still largely mysterious role of spatial positioning in genome activity and stability.
http://www.cell.com/abstract/S0092-8674(04)00944-4
Location, Location, Location http://www.sciencemag.org/content/326/5957/1205.short
Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis
http://dev.biologists.org/content/135/19/3209.abstract
Spatial Control of Cytokinesis by Cdr2 Kinase and Mid1/Anillin Nuclear Export
http://www.cell.com/current-biology/abs ... 09)00985-3
Three-dimensional organization of the mammalian nucleus in normal and tumor cells.
http://atlasgeneticsoncology.org/Deep/3 ... 20053.html
On emerging nuclear order
Increasing evidence suggests that the arrangement of chromosomes, gene loci, and nuclear bodies is nonrandom and exhibits features of self-organization in space and time...
Although mechanisms governing spatial positioning and how specific nuclear subcompartments at the periphery influence transcriptional state are not well understood, they appear to be important regulatory events in development.
http://jcb.rupress.org/content/192/5/711.full
Micropatterned environments in cell biology
http://www.seas.upenn.edu/~chenlab/pdf/ ... vMat04.pdf
LOL even the people from the wacko type sites are getting in the action....
Genetics: Does DNA also encode mathematical values of lengths, distances and angles?
Each organism eventually has a certain physical shape and in humans, this is inevitably 2 arms, 2 legs, a head, 2 ears, 2 eyes, hands, fingers, etc. Now these are obviously the external shape and appearance of the organism. But there are also internal 3 dimensional structures e.g. blood vessels, the brain, the heart, the liver, kidneys, stomach, etc, etc.
So where is the information stored that determines the "physical" 3 dimensional shape (internal and external) of the organism ? Presumably also somewhere within the DNA How is this information retrieved and used ?
The completed arm will have a physical shape thats recognizable as an arm which means that during the entire process of creating the arm, millions of cells will become involved and will require knowledge of their position in space and their position relative to all the other cells busily working away at creating their part of the arm. Otherwise if cells were allowed to simply divide and position themselves randomly, the foetus would most likely end up with a blob or some other weird shape for an arm.
The fact that an arm most times develops in the right place and looks like an arm, must mean that every cell that played a part in the construction of that arm must have also been supplied or had access to spatial positioning information and some kind of coordination system ... information that would say "get x number of cells to divide but only in THIS direction only and then stop ... then get y number of cells to divide but only in THIS different direction, then stop." http://www.abovetopsecret.com/forum/thread518463/pg1
Maybe they aren't so wacko after all....
Spatially dependent activation of the patterning protease, Easter
Easter is the final protease in a serine protease cascade in which initial reaction steps appear not to be ventrally restricted, but where Easter activity is promoted ventrally through the action of a spatial cue at an unknown step in the pathway. Here, biochemical studies demonstrate that this spatial control occurs at or above the level of Easter zymogen activation, rather than through direct promotion of Easter's catalytic activity against the signaling ligand. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644372/